List of all examples

This page contains all individual examples of the seventeen basic modifier mechanisms mentioned in this website. The inclusive table is simpler than the individual tables as it does not show the name given the mechanism by the authors and the summary of relevant parameters. The first column shows the name of the mechanism as acronym, which together with the reference serves to identify a row that can be found in the table dedicated to the particular mechanism showing more details.
Each item, text or number, can be searched case-insensitive and all columns can be sorted. For instance, this facilitates locating all entries that belong to an enzyme by typing its name or the EC-number, or all entries of a given modifier. New data are added to the end of the table, but the sorting and search facilities can be used to locate the mechanisms by typing their acronyms.

MechanismEnzyme
Species
EC no.Modifier
(Substrate)
[Notes, if any]
References
LCaICatechol 1,2-dioxygenase
Acinetobacter baylyi
1.13.11.44-Chlorocatechol
(4-Chloroaniline)
Hongsawat
(2011)
LCaI3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+)
Rattus norvegicus
1.3.1.22Aryl steroid 1
(Testostrerone)
Brandt
(1990)
LCaI3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+)
Rattus norvegicus
1.3.1.22Aryl steroid 1
(NADPred)
Brandt
(1990)
LCaI3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+)
Rattus norvegicus
1.3.1.22Aryl steroid 2
(Testosterone)
Brandt
(1990)
LCaI3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+)
Rattus norvegicus
1.3.1.22Aryl steroid 2
(NADPred)
Brandt
(1990)
LCaIInositol-phosphate phosphatase
Bos taurus
3.1.3.25Li+
(Racemic myo-inositol 1-phosphate)
Leech
(1993)
LCaIInositol-phosphate phosphatase
Bos taurus
3.1.3.25Li+
(myo-inositol 1-phosphate)
Leech
(1993)
LCaIInositol-phosphate phosphatase
Bos taurus
3.1.3.25Li+
(Adenosine-2'-phosphate)
Leech
(1993)
LCaIAlkaline phosphatase
Homo sapiens
3.1.3.1L-Tryptophan
(Phenyl phosphate)
Lin
(1971)
LCaIGamma-glutamyltransferase
Homo sapiens
2.3.2.2OU749
(L-glutamic acid-γ-4-nitroanilide)
[Transpeptidase reaction]
King
(2009)
LCaIGamma-glutamyltransferase
Homo sapiens
2.3.2.2OU749
(D-glutamic acid-γ-4-nitroanilide)
[Hydrolysis reaction]
Wickham
(2012)
LCaIGamma-glutamyltransferase
Homo sapiens
2.3.2.2Sodium benzosulfonamide
(L-glutamic acid-γ-4-nitroanilide)
[Transpeptidase reaction]
Wickham
(2012)
LCaIGamma-glutamyltransferase
Homo sapiens
2.3.2.2Sodium benzosulfonamide
(D-glutamic acid-γ-4-nitroanilide)
[Hydrolysis reaction]
Wickham
(2012)
LSpIAlpha,alpha trehalase
Chironomus riparius
3.2.1.287-deoxy-epi-casuarine = Compound 6
(Trehalose)
D'Adamio
(2015)
LSpICoagulation factor IXa
Homo sapiens
3.4.21.27Aprotinin
(L-Pyroglutamyl-L-Pro-L-Arg-p-nitroanilide)
Ogawa
(2005)
LSpICholinesterase
Homo sapiens
3.1.1.8Tosyllysine chloromethyl ketone
(Butyrylthiocholine)
Çokuğraş
(2004)
LSpIAldehyde oxidase
Homo sapiens
1.2.3.16-Chloroquinazolinone
(Phtalazine)
Barr
(2011)
LSpISpermine synthase
Bos taurus
2.5.1.22Spermine - reaction product
(Decarboxylated adenosylmethionine)
Pajula
(1983)
LSpITyrosinase
Homo sapiens
1.14.18.1HTS05357
(L-Dopa)
Sun
(2014)
LSpIDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Trp2,Ile3-Tat(1-9) = MWIVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LSpIDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5TXA2-R(1-9) = MWPNGSSLG
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LSpIDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Met-Trp1-IL-2(1-8) = MWPTSSSTK
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LSpIDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Met-Trp-Pro
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LSpIAcetylcholinesterase
Torpedo californica
3.1.1.7Edrophonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
LSpIAcetylcholinesterase
Torpedo californica
3.1.1.7Phenyltrimethylammonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
LSpIAcetylcholinesterase
Torpedo californica
3.1.1.7N-Methylacridinium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
LSpIGamma-glutamyltransferase
Homo sapiens
2.3.2.2OU749
(Gly-Gly)
King
(2009)
LSpIThrombin
Homo sapiens
3.4.21.5Recombinant hirudin
(Tos-Gly-Pro-Arg-7-amino-4-methyl-coumarylamide)
Schmitz
(1991)
LSpIThrombin
Homo sapiens
3.4.21.5Hirudin1-47 fragment
(Tos-Gly-Pro-Arg-7-amino-4-methyl-coumarylamide)
Schmitz
(1991)
LSpIThrombin
Homo sapiens
3.4.21.5Hirudin45-65 fragment
(Fibrinogen Aα)
Schmitz
(1991)
LSpIThrombin
Homo sapiens
3.4.21.5Hirudin1-47 fragment
(Fibrinogen Aα)
Schmitz
(1991)
LSpIProtein-lysine desuccinylase (NAD+)
Homo sapiens
2.4.2.B14Compound 39
(Abz-GVLK(glutaryl)AY(NO2)GV-H2)
Kalbas
(2018)
LSpIProtein-lysine desuccinylase (NAD+)
Homo sapiens
2.4.2.B14Compound 39.2
(Abz-GVLK(glutaryl)AY(NO2)GV-H2)
Kalbas
(2018)
LSpICoagulation factor Xa
Homo sapiens
3.4.21.6BAY 59-7939 = Rivaroxaban
(N-Methoxycarbonyl-D-cyclohexylalanyl-
Gly-Arg-4-nitroanilide acetate)
Perzborn
(2005)
LSpIAcylglycerol lipase
Homo sapiens
3.1.1.23Compound 17b
(4-Nitrophenylacetate)
Granchi
(2016)
HMxD(A/I)Cathepsin K
Homo sapiens
3.4.22.38Chondroitin sulfate
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2010)
HMxD(A/I)Cathepsin K
Homo sapiens
3.4.22.38Dextran sulfate
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2010)
HMxD(A/I)Cathepsin K
Homo sapiens
3.4.22.38Heparin
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2010)
HMxD(A/I)Coagulation factor IXa
Homo sapiens
3.4.21.22ISIS 2302
(CH3-SO2-(D)-CHG-Gly-Arg-pNA)
Sheehan
(2001)
HMxD(A/I)3-Phosphoshikimate 1-carboxyvinyltransferase
Bacillus subtilis
2.5.1.19Glyphosate
(Shikimate-3-phosphate)
Fischer
(1987)
HMxD(A/I)D-amino acid oxidase
Homo sapiens
1.4.3.3Risperidone
(D-Alanine)
Abou El-Magd
(2010)
HMxD(A/I)Arachidonate 15-lipoxygenase
Homo sapiens
1.13.11.3313-(S)-HODE
(Arachidonic acid)
Joshi
(2013)
HMxD(A/I)Laccase
Trametes versicolor
1.10.3.2Arsenate (As5+)
(2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid))
Wang
(2016)
HMxD(A/I)Lipopolysaccharide heptosyltransferase I
Escherichia coli
2.4.99.B6Hexene-β-D-glucopyranoside
(ADP-L-glycero-D-manno-heptose)
Nkosana
(2018)
HMxD(I/A)Arachidonate 15-lipoxygenase
Homo sapiens
1.13.11.3313-(S)-HODE
(γ-linolenic acid)
Joshi
(2013)
HMxD(I/A)Arachidonate 15-lipoxygenase
Homo sapiens
1.13.11.3313-(S)-HOTrE(γ)
(γ-linolenic acid)
Joshi
(2013)
HMxD(I/A)Glutathione transferase
Mus musculus
2.5.1.18Ethacrinic acid
(1-Chloro-2,4-dinitrobenzene)
Phillips
(1991)
HMxD(I/A)Cathepsin K
Homo sapiens
3.4.22.38NSC13345
(Abz–HPGGPQ–EDDnp)
Novinec
(2014b)
HMxD(I/A)Cathepsin K
Homo sapiens
3.4.22.38(2-Biphenylylmethyl) malonic acid
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014a)
HMxD(I/A)Cathepsin K
Homo sapiens
3.4.22.381,4,7,9B-Tetraazaphenalene
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014a)
HMxD(I/A)Chymotrypsin
Not specified
3.4.21.11α-Napthylamine
(N-Acetylglycine ethylester)
Martinek
(1971)
HMxD(I/A)Chymotrypsin
Not specified
3.4.22.11Phenol
(N-Acetylglycine ethylester)
Martinek
(1971)
HMxD(I/A)Cholinesterase
Homo sapiens
3.1.1.8Benzalkonium
(3-(Acetamido) N,N,N-trimethylanilinium)
Masson
(2008)
HMxD(I/A)Acetylcholinesterase
Torpedo californica
3.1.1.7Decamethonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
HMxD(I/A)Acetylcholinesterase
Torpedo californica
3.1.1.7Hexamethonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
HMxD(I/A)Acetylcholinesterase
Torpedo californica
3.1.1.7Decyltrimethyl-ammonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
HMxD(I/A)Acetylcholinesterase
Torpedo californica
3.1.1.7Hexyltrimethyl-ammonium
(7-Acetoxy-4-methylcoumarin)
Berman
(1990)
HMxD(I/A)Aldehyde dehydrogenase (NAD+)
Homo sapiens
1.2.1.3Alda-1
(Propanal)
Belmont-Dí­az
(2016)
HMxD(I/A)Gamma-glutamyl transferase
Homo sapiens
2.3.2.2Compound 11
(D-glutamic acid γ-4-nitro-anilide HCl)
Wickham
(2012, 2013)
HMxD(I/A)Gamma-glutamyl transferase
Homo sapiens
2.3.2.2Compound 14
(Glutathione)
Wickham
(2012, 2013)
LMx(Sp>Ca)IPeroxiredoxin
Homo sapiens
1.11.1.15Catechol
(H2O2)
Chow
(2016)
LMx(Sp>Ca)IAlpha,alpha trehalase
Chironomus riparius
3.2.1.28Compound 7
(Trehalose)
D'Adamio
(2015)
LMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Cholic acid
(Leu-Met)
Nakanishi
(1989)
LMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Deoxycholic acid
(Leu-Met)
Nakanishi
(1989)
LMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Chenodeoxycholic acid
(Leu-Met)
Nakanishi
(1989)
LMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Deoxycholic acid
(Leu-Gly)
Nakanishi
(1989)
LMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Pararosaniline
(Acetylthiocholine)
Küçükkilinç
(2007)
LMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Pararosaniline
(Butyrylthiocholine)
Küçükkilinç
(2005)
LMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Malachite green
(Butyrylthiocholine)
Küçükkilinç
(2005)
LMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Ethopropazine
(Butyrylthiocholine)
Küçükkilinç
(2007)
LMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Malachite green
(Acetylthiocholine)
Küçükkilinç
(2008)
LMx(Sp>Ca)ICoagulation factor XIa
Homo sapiens
3.4.21.27Aprotinin
(Coagulation factor IX)
Ogawa
(2005)
LMx(Sp>Ca)IMemapsin 2
Homo sapiens
3.4.23.46Pepstatin A methylester: pH = 6.5, 22°C
(C100)
Tian
(2002)
LMx(Sp>Ca)IMemapsin 2
Homo sapiens
3.4.23.46Pepstatin A methylester: pH = 6.5, 37°C
(C100)
Tian
(2002)
LMx(Sp>Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Domperidone
(Phtalazine)
Barr
(2011)
LMx(Sp>Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Chlorpromazine
(Phtalazine)
Barr
(2011)
LMx(Sp>Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Clozapine
(Phtalazine)
Barr
(2011)
LMx(Sp>Ca)ISpermine synthase
Bos taurus
2.5.1.22Spermine - reaction product
(Spermidine)
Pajula
(1983)
LMx(Sp>Ca)ISpermine synthase
Bos taurus
2.5.1.22 5'-methylthioadenosine - reaction product
(Decarboxylated adenosylmethionine)
Pajula
(1983)
LMx(Sp>Ca)ITyrosinase
Homo sapiens
1.14.18.1Kojic acid
(L-Dopa)
Sun
(2014)
LMx(Sp>Ca)IButane-utilizing bacterial
cultures

Butane
(1,1-dichloroethylene)
Kim
(2002)
LMx(Sp>Ca)IButane-utilizing bacterial
cultures

Butane
(1,1-dichloroethane)
Kim
(2002)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Lys2-Tat(1-9): MKPVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Trp2-Tat(1-9): MWPVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Met-Trp1-G-CSF(1-8): MWPLGPASS
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Met-IL-2(1-12): MAPTSSSTKKTQL
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Met-Trp-Val
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Tat(1-9): MDPVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Tat(1-9): MDPVDPNIE
(Gly-Pro-R110-CO-(CH2)4Cl)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Trp1-Tat(1-9): WDPVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Gly3-Tat(1-9): MDGVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)IDipeptidyl-peptidase IV
Homo sapiens
3.4.14.5Ile3-Tat(1-9): MDIVDPNIE
(Ala-Pro-p-nitroanilide)
Lorey
(2003)
LMx(Sp>Ca)Iβ-Lactamase
Bacillus cereus 5B6
3.5.2.6Compound 6a
(Nitrocefin)
Siemann
(2002)
LMx(Sp>Ca)Iβ-Lactamase
Bacillus cereus 5B6
3.5.2.6Compound 11c
(Nitrocefin)
Siemann
(2002)
LMx(Sp>Ca)ICatechol 1,2-dioxygenase
Acinetobacter baylyi
1.13.11.14-Chloroaniline
(3,4-Dichloroaniline)
Hongsawat
(2011)
LMx(Sp>Ca)ICruzipain
Tripanosoma cruzi
3.4.22.51Fukugetin
(Cbz-Phe-Arg-7-amino-4-methyl
coumarylamide)
Assis
(2013)
LMx(Sp>Ca)IS-(hydroxymethyl)glutathione dehydrogenase
Homo sapiens
1.1.1.284Resveratrol
(Doxorubicin)
Ito
(2013)
LMx(Sp>Ca)ILinoleate 13S-lipoxygenase
Glycine max
1.13.11.12(Z)-9-palmitoleyl sulfate
(Linoleic acid)
Ruddat
(2003)
LMx(Sp>Ca)INADH:ubiquinone reductase (H+-translocating)
Escherichia coli
1.6.5.3Zn2+
(NADred)
Schulte
(2014)
LMx(Sp>Ca)INeurolysin
Rattus norvegicus
3.4.24.16R2
(Internally quenched peptide containing the neurotensin sequence)
Hines
(2014)
LMx(Sp>Ca)IAdenylate cyclase
Homo sapiens
4.6.1.1Bithionol
(ATP)
Kleinboelting
(2016)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Edrophonium
( Acetylthiocholine)
Berman
(1990)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Phenyltrimethyl-ammonium
( Acetylthiocholine)
Berman
(1990)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7N-Methylacridinium
( Acetylthiocholine)
Berman
(1990)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Decamethonium
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Hexamethonium
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Decyltrimethylammonium
(Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Hexyltrimethylammonium
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7Propidium
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7d-Tubocurarine
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Tacrine
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Galanthamine
( Acetylthiocholine)
Pietsch
(2005)
LMx(Sp>Ca)IProtein-glutamine gamma-glutamyl-transferase
Homo sapiens
2.3.2.13Compound 5c
(Compound 5b)
Wodtke
(2016)
LMx(Sp>Ca)ITyrosinase
Agaricus bisporus
1.14.18.1Kojic acid
(L-Dopa)
Liu
(2017)
LMx(Sp<Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Cholic acid
(Leu-p-nitroanilide)
Nakanishi
(1989)
LMx(Sp<Ca)IMemapsin 2
Homo sapiens
3.4.23.46Compound 1; pH = 6.5, 22°C
(C100)
Tian
(2002)
LMx(Sp<Ca)IAldehyde oxidase
Homo sapiens
1.2.3.12,6-Dichlorophenolindophenol
(Phtatalazine)
Barr
(2011)
LMx(Sp<Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Estradiol
(Phtatalazine)
Barr
(2011)
LMx(Sp<Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Menadione
(Phtatalazine)
Barr
(2011)
LMx(Sp<Ca)IAldehyde oxidase
Homo sapiens
1.2.3.1Ethinyl estradiol
(Phtatalazine)
Barr
(2011)
LMx(Sp<Ca)ISpermine synthase
Bos taurus
2.5.1.225'-methylthioadenosine - reaction product
(Spermidine)
Pajula
(1983)
LMx(Sp<Ca)ITyrosinase
Homo sapiens
1.14.18.14-Acetylphenylthiourea
(L-Dopa)
[see examples of LMx(Sp<Ca)I for comments on the modifier]
Sun
(2014)
LMx(Sp<Ca)IButane-utilizing
bacterial cultures
Butane
(1,1,1,-Trichloroethane)
Kim
(2002)
LMx(Sp<Ca)IABC-type quaternary amine transporter
Homo sapiens
7.6.2.9N-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide
(γ-Aminobutyric acid)
Kragholm
(2013)
LMx(Sp=Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Deoxycholic acid
(Leu-p-nitroanilide)
Nakanishi
(1989)
LMx(Sp=Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Chenodeoxycholic acid
(Leu-p-nitroanilide)
Nakanishi
(1989)
LMx(Sp=Ca)ICaspase-7
Homo sapiens
3.4.22.60NSC321205
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-7
Homo sapiens
3.4.22.60NSC277584
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-7
Homo sapiens
3.4.22.60NSC310547
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-9-LZ
Homo sapiens
3.4.22.62NSC321205
(Ac-LEHD-AFC)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-9-LZ
Homo sapiens
3.4.22.62NSC277584
(Ac-LEHD-AFC)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-9-LZ
Homo sapiens
3.4.22.62NSC310547
(Ac-LEHD-AFC)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-9
Homo sapiens
3.4.22.62NSC321205
(Ac-LEHD-AFC)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-2
Homo sapiens
3.4.22.55NSC277584
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-2
Homo sapiens
3.4.22.55NSC321206
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)ICaspase-2
Homo sapiens
3.4.22.55NSC310547
((Z-DEVD)2Rh110)
Feldman
(2012)
LMx(Sp=Ca)IMemapsin 2
Homo sapiens
3.4.23.46L-685,458; pH = 6.5, 37°C
(C100)
Tian
(2002)
LMx(Sp=Ca)IMemapsin 2
Homo sapiens
3.4.23.46Compound 2; pH = 6.5, 37°C
(C100)
Tian
(2002)
LMx(Sp=Ca)IMemapsin 2
Homo sapiens
3.4.23.46Compound 3; pH = 6.5, 37°C
(C100)
Tian
(2002)
LMx(Sp=Ca)IMemapsin 2
Homo sapiens
3.4.23.46Compound 4; pH = 6.5, 37°C
(C100)
Tian
(2002)
LMx(Sp=Ca)IGlycogen phosphorylase
Neurospora crassa
2.4.1.1Uridine diphosphate glucose
(Glycogen)
Gold
(1974)
HSpIAcetylcholinesterase
Torpedo californica
3.1.1.7Propidium
(7-acetoxy-4-methyl-coumarin)
Berman
(1990)
HSpICathepsin K
Homo sapiens
3.4.22.38Compound 6
(Cbz-Phe-Arg-7-amino-4-methyl-
coumarylamide)
Novinec
(2014)
HSpICoagulation factor VIIa
Homo sapiens
3.4.21.21Peptide A-183 = EEWEVLCWTWETCER
(N-Methylsulfonyl-D-Phe-Gly-Arg-4-
nitroanilide acetate)
Dennis
(2001)
HSpIDNA helicase
Human papillomavirus 6 E1
3.6.4.12Bisphenylsulfonaceticacid derivative 4
(ATP)
White
(2005)
HSpIDNA helicase
Human papillomavirus 6 E1
3.6.4.12Bisphenylsulfonaceticacid derivative 6
(ATP)
White
(2005)
HSpIDNA helicase
Human papillomavirus 6 E1
3.6.4.12Bisphenylsulfonaceticacid derivative 7
(ATP)
White
(2005)
HSpIThrombin
Homo sapiens
3.4.21.5Nα-acetyl desulfo hirudin 45-65
(Tos-Gly-Pro-Arg-p-nitroanilide)
DiMaio
(1990)
HSpIThrombin
Bos taurus
3.4.21.5Nα-acetyl desulfo hirudin 45-65
(Tos-Gly-Pro-Arg-p-nitroanilide)
DiMaio
(1990)
HSpINAD(P)H oxidase
Mycobacterium tuberculosis
1.6.3.1NADox
(NADred)
Worcel
(1965)
HMx(Sp>Ca)IStratum corneum chymotryptic enzyme
Homo sapiens
3.4.21.117Antileukoproteinase
(MeO-Succinyl-Arg-Pro-Tyr-p-nitroanilide)
Franzke
(1996)
HMx(Sp>Ca)INon-specific serine/threonine protein kinase
Rattus norvegicus
2.7.11.1Heparin fragment , 6-mer
(Peptide RRRADDSDDDDD)
O'Farrel
(1999)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Gold thiomalate
(t-Butyloxycarbonyl-alanyl-p-nitrophenyl ester)
Baici
(1981)
HMx(Sp>Ca)ICoagulation factor Xa
Homo sapiens
3.4.21.6Antistasin
(CH3SO2-Leu-Gly-Arg-p-nitroanilide)
Dunwiddie
(1989)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Suramin
(Suc-Ala-Ala-Ala-p-nitroanilide)
Cadéne
(1997)
HMx(Sp>Ca)ICathepsin G
Homo sapiens
3.4.21.20Suramin
(Suc-Ala-Ala-Pro-Phe-pnitroanilide)
Cadéne
(1997)
HMx(Sp>Ca)IMyeloblastin
Homo sapiens
3.4.21.76Suramin
(MeO-Suc-Ala-Ala-Pro-Val-thiobenzylester)
Cadéne
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Dermatan sulfate, Mr= 31,000; 62 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Chondroitin 4-sulfate, Mr =18,000; 36 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Chondroitin 6-sulfate, Mr = 29,000; 58 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Dermatan sulfate, Mr = 10,200; 20 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Chondroitin 4,6-disulfate, Mr = 27,600; 46 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Dermatan 4,6-disulfate, Mr = 25,000; 41 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Chondroitin N,4-disulfate, Mr = 6,900; 12 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Dermatan N,4-disulfate, Mr = 6,600; 12 DU/chain
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Kostoulas
(1997)
HMx(Sp>Ca)ICaspase-2
Homo sapiens
3.4.22.55AR_F8, designed ankyrin repeat
(Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-methylcoumarylamide)
Schweizer
(2007)
HMx(Sp>Ca)IADAMTS 13 endopeptidase
Homo sapiens
3.4.24.87 cVWF6
(a synthetic peptide)
Gao
(2006)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Meldola blue
(Acetylthiocholine)
Küçükkilinç
(2007)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Nile blue
(Acetylthiocholine)
Küçükkilinç
(2007)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Methylene blue
(Acetylthiocholine)
Küçükkilinç
(2007)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Gallamine triethiodide
(Acetylthiocholine)[without acetonitrile]
Pietsch
(2009)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 11
(Acetylthiocholine)
Gonzàlez-Tanarro
(2011)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 12
(Acetylthiocholine)
Gonzàlez-Tanarro
(2011)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 13
(Acetylthiocholine)
Gonzàlez-Tanarro
(2011)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 14
(Acetylthiocholine)
Gonzàlez-Tanarro
(2011)
HMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Cholic acid
(Leu-Gly)
Nakanishi
(1989)
HMx(Sp>Ca)IAminopeptidase N
Homo sapiens
3.4.11.2Chenodeoxycholic acid
(Leu-Gly)
Nakanishi
(1989)
HMx(Sp>Ca)ISpermidine synthase
Bos taurus
2.5.1.16Spermidine
(Putrescine)
Raina
(1984)
HMx(Sp>Ca)ISpermidine synthase
Bos taurus
2.5.1.16Spermidine
(Decarboxylated adenosylmethionine)
Raina
(1984)
HMx(Sp>Ca)IPeroxiredoxin
Homo sapiens
1.11.1.154-tert-butylcatecholChow
(2016)
HMx(Sp>Ca)IAlpha,alpha trehalase
Chironomus riparius
3.2.1.286-epi-casuarine
(H2O2)
D'Adamio
(2015)
HMx(Sp>Ca)IAlpha,alpha trehalase
Chironomus riparius
3.2.1.287-deoxycasuarine
(Trehalose)
D'Adamio
(2015)
HMx(Sp>Ca)IEthanolamine-phosphate phospholyase
Homo sapiens
4.2.3.2Phosphate
(O-phosphoethanolamine)
[pH = 8.8]
Schiroli
(2015)
HMx(Sp>Ca)ICathepsin K
Homo sapiens
3.4.22.38Compound 1
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014)
HMx(Sp>Ca)ICathepsin K
Homo sapiens
3.4.22.38Compound 2
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014)
HMx(Sp>Ca)ICathepsin K
Homo sapiens
3.4.22.38Compound 3
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014)
HMx(Sp>Ca)ISterol esterase
Sus scrofa domestica
3.1.1.13Compound 4a
(p-Nitrophenyl butyrate)
Heng
(2011)
HMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Serotonin
(o-Nitrophenylacetate)
Masson
(2008)
HMx(Sp>Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Methyl green
(Acetylthiocholine)
Küçükkilinç
(2008)
HMx(Sp>Ca)ILinoleate 13S-lipoxygenase
Glycine max
1.13.11.12Oleyl sulfate
(Linoleic acid)
Mogul
(2000)
HMx(Sp>Ca)I'Cytochrome P450'
Rattus norvegicus
1.14.14.1 (possibly)Primaquine
(Aminopyrine)
Murray
(1986)
HMx(Sp>Ca)ICoagulation factor XIa
Homo sapiens
3.4.21.27Coagulation factor IX
(L-Pyroglutamyl-L-Pro-L-Arg-p-nitroanilide)
Ogawa
(2005)
HMx(Sp>Ca)ICoagulation factor XIa
Homo sapiens
3.4.21.27Active site-inhibited factor IXa = factor IXai
(L-Pyroglutamyl-L-Pro-L-Arg-p-nitroanilide)
Ogawa
(2005)
HMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Tosyllysine chloromethyl ketone
( Butyrylthiocholine)
[native enzyme]
Cengiz
(1997)
HMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Tosylphenylalanine chloromethyl ketone
( Butyrylthiocholine)
[native enzyme]
Cengiz
(1997)
HMx(Sp>Ca)ICholinesterase
Homo sapiens
3.1.1.8Tosyllysine chloromethyl ketone
( Butyrylthiocholine)
[heat desensitized enzyme, 24 h, 45°C]
Çokuğraş
(2004)
HMx(Sp>Ca)ICoagulation factor VIIa
Homo sapiens
3.4.21.21Peptide A-183
EEWEVLCWTWETCER
(Coagulation factor X)
Dennis
(2001)
HMx(Sp>Ca)ICellulose 1,4-beta-cellobiosidase
Trichoderma reesei
3.2.1.91Cellobiose
(Cellulose)
[reaction product, present initially]
Bezerra
(2011)
HMx(Sp>Ca)ICellulose 1,4-beta-cellobiosidase
Trichoderma reesei
3.2.1.91Cellobiose
(Cellulose)
[reaction product, not present initially]
Bezerra
(2011)
HMx(Sp>Ca)IPapain
Carica papaya
3.4.22.1Fukugetin
( Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Assis
(2013)
HMx(Sp>Ca)IAcetolactate synthase
Escherichia coli
2.2.1.6Valine
(Pyruvate)
Mendel
(2001)
HMx(Sp>Ca)IABC-type quaternary amine transporter
Homo sapiens
7.6.2.9Tiagabine
(γ-Aminobutyric acid)
Kragholm
(2013)
HMx(Sp>Ca)ISerine racemase
Homo sapiens
5.1.1.181,4-dihydronicotinamide mononucleotide
(L-Serine)
Bruno
(2016)
HMx(Sp>Ca)ICathepsin B
Homo sapiens
3.4.22.1DARPin 8h6
(Cbz-Arg-Arg-7-amino-4-methylcoumarylamide)
Kramer
(2017)
HMx(Sp>Ca)ICathepsin B
Mus musculus
3.4.22.1DARPin 8h6
(Cbz-Arg-Arg-7-amino-4-methylcoumarylamide)
Kramer
(2017)
HCaIGlutamate dehydrogenase (NAD(P)+)
Not specified
1.4.1.3GTP
(NADPred)
Frieden
(1962, 1963)
HCaICathepsin K
Homo sapiens
3.4.22.38Compound 7
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014)
HCaICathepsin K
Homo sapiens
3.4.22.38Compound 8
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2014)
HCaIPenicillin amidase
Escherichia coli ATC11105
3.5.1.11PEG-400
(p-dimethylamino-benzaldehyde)
Kazan
(1997)
HCaIPenicillin amidase
Escherichia coli ATC11105
3.5.1.11PEG-4000
(p-dimethylamino-benzaldehyde)
Kazan
(1997)
HCaIPenicillin amidase
Escherichia coli ATC11105
3.5.1.11PEG-10,000
(p-dimethylamino-benzaldehyde)
Kazan
(1997)
HCaIGlutathione-disulfide reductase
Saccharomyces cerevisiae
1.8.1.7Safranin O
(oxidized L-Glutathione)
Lüönd
(1998)
HCaIGlutathione-disulfide reductase
Saccharomyces cerevisiae
1.8.1.7Thionin O
(oxidized L-Glutathione)
Lüönd
(1998)
HCaIGlutathione-disulfide reductase
Saccharomyces cerevisiae
1.8.1.76-Anilino-5,8-quinolinedione
(oxidized L-Glutathione)
Lüönd
(1998)
HCaIGlutathione-disulfide reductase
Saccharomyces cerevisiae
1.8.1.72-Anilino-1,4-naphthoquinone
(oxidized L-Glutathione)
Lüönd
(1998)
HCaIXanthine oxidase
Bos taurus
1.2.3.2Xanthine
(O2)
[substrate inhibition by xanthine]
Morpeth
(1983)
HCaINADH:ubiquinone reductase (non-electrogenic)
Saccharomyces cerevisiae
1.6.5.9Flavone
(NADred)
Velázquez
(2001)
HCaI4-Hydroxy-tetrahydro-dipicolinate synthase
Escherichia coli
4.3.3.7Lysine
(Pyruvate)
Dobson
(2004)
HCaICathepsin B
Homo sapiens
3.4.22.1Cyclopalladated bisphosphinic complex
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Bincoletto
(2005)
HCaIThrombin
Homo sapiens
3.4.21.5Hirudin45-65 fragment
(Tos-Gly-Pro-Arg-7-amino-4-methylcoumarylamide)
Schmitz
(1991)
HCaILipopolysaccharide heptosyltransferase I
Escherichia coli
2.4.99.B6Hexene-β-D-glucopyranoside
(O-deacylated E. coli Kdo2-Lipid A)
Nkosana
(2018)
HMx(Sp<Ca)ILaccase
Trametes versicolor
1.10.3.2Arsenite
( 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid))
Wang
(2016)
HMx(Sp<Ca)IGlycerol kinase
Escherichia coli
2.7.1.30Glucose-specific phosphocarrier protein
(MgATP)
Pettigrew
(2009)
HMx(Sp<Ca)IGlycerol kinase
Escherichia coli
2.7.1.30Glucose-specific phosphocarrier protein
(MgATP)
Pettigrew
(2009)
HMx(Sp<Ca)I'Cytochrome P450'
Rattus norvegicus
1.14.14.1 (possibly)p-Nitrobenzoate
(Zoxazolamine)
Sternson
(1976)
HMx(Sp<Ca)ICoagulation factor IXa (FIXa)
Homo sapiens
3.4.21.22Nitrophorin-2
(N-α-benzyloxycarbonyl-(D-Arg-Gly-Arg-p-nitroanilide)
[one of 5 assays conditions, see the original table]
Zhang
(1998)
HMx(Sp<Ca)ICoagulation factor IXa (FIXa)
Homo sapiens
3.4.21.22Nitrophorin-2
(N-α-benzyloxycarbonyl-(D-Arg-Gly-Arg-p-nitroanilide)
[one of 5 assays conditions, see the original table]
Zhang
(1998)
HMx(Sp<Ca)ICoagulation factor IXa (FIXa)
Homo sapiens
3.4.21.22Nitrophorin-2
(one of 5 assays conditions, see the original table)(N-α-benzyloxycarbonyl-(D-Arg-Gly-Arg-p-nitroanilide)
[one of 5 assays conditions, see the original table]
Zhang
(1998)
HMx(Sp<Ca)ICoagulation factor IXa (FIXa)
Homo sapiens
3.4.21.22Nitrophorin-2
(N-α-benzyloxycarbonyl-(D-Arg-Gly-Arg-p-nitroanilide)
[one of 5 assays conditions, see the original table]
Zhang
(1998)
HMx(Sp<Ca)ICoagulation factor IXa (FIXa)
Homo sapiens
3.4.21.22Nitrophorin-2
(N-α-benzyloxycarbonyl-(D-Arg-Gly-Arg-p-nitroanilide)
[one of 5 assays conditions, see the original table]
Zhang
(1998)
HMx(Sp<Ca)IThrombin
Homo sapiens
3.4.21.5p -Mercaptobenzoic acid-coated gold nanoparticles
(H-D-Phe-Pip-Arg-p -nitroanilide)
Lira
(2018)
HMx(Sp<Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 9
(Acetylthiocholine)
González-Tanarro
(2011)
HMx(Sp<Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 10
(Acetylthiocholine)
González-Tanarro
(2011)
HMx(Sp<Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 39
(Acetylthiocholine)
Pietsch
(2005)
HMx(Sp<Ca)IAcetylcholinesterase
Electrophorus electricus
3.1.1.7Compound 40
(Acetylthiocholine)
Pietsch
(2005)
HMx(Sp<Ca)Iβ-Lactamase
Pseudomonas aeruginosa
3.5.2.6Cherry-NbVIM_38 =
single-domain antibody fragment, camelid nanobody
(Cephalothin)
Sohier
(2013)
HMx(Sp<Ca)IPeroxidase
Armoracia rusticana
1.11.1.7Melamine
(o-Phenylenediamine)
[pH = 4.3]
Karaseva
(2003)
HMx(Sp=Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37Pentosan polysulfate
(t-Butyloxycarbonyl-Ala-p-nitrophenyl ester)
Baici
(1981)
HMx(Sp=Ca)I4-Hydroxy-tetrahydro-dipicolinate synthase
Escherichia coli
4.3.3.7Lysine
((S)-aspartate-β-semialdehyde)
Dobson
(2004)
HMx(Sp=Ca)IPlasmin
Homo sapiens
3.4.21.7Modified dextran RG1503, Mr = 47,000
((D)-Val-Leu-Lys-p-nitroanilide)
[Binding stoichiometry = 6:1; tightly bound modifier]
Ledoux
(2000)
HMx(Sp=Ca)IPlasmin
Homo sapiens
3.4.21.7Modified dextran RG1192, Mr = 140,000
((D)-Val-Leu-Lys-p-nitroanilide)
[Binding stoichiometry = 20:1; tightly bound modifier]
Ledoux
(2000)
HMx(Sp=Ca)INADH:ubiquinone reductase (non-electrogenic)
Saccharomyces cerevisiae
1.6.5.9Flavone
(2,6-Dichlorophenolindophenol)
Velázquez
(2001)
HMx(Sp=Ca)IAcetylcholinesterase
Torpedo californica
3.1.1.7d-Tubocurarine
(7-acetoxy-4-methylcoumarin)
Berman
(1990)
HMx(Sp=Ca)ISpermidine synthase
Bos taurus
2.5.1.165'-Methythioadenosine
(Putrescine)
Raina
(1984)
HMx(Sp=Ca)ISpermidine synthase
Bos taurus
2.5.1.165'-Methythioadenosine
(Decarboxylated adenosylmethionine)
Raina
(1984)
HMx(Sp=Ca)INon-specific serine/ threonine protein kinase
Rattus norvegicus
2.7.11.1Heparin fragment, 20-mer
(Peptide RRRADDSDDDDD)
O'Farrel
(1999)
HMx(Sp=Ca)ICaspase-1
Homo sapiens
3.4.22.36NSC321205
(Acetyl-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarylamide)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-1
Homo sapiens
3.4.22.36NSC277584
(Acetyl-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarylamide)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-1
Homo sapiens
3.4.22.36NSC321206
(Acetyl-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarylamide)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-1
Homo sapiens
3.4.22.36NSC310547
(Acetyl-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarylamide)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-3
Homo sapiens
3.4.22.56NSC321205
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-3
Homo sapiens
3.4.22.56NSC277584
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-3
Homo sapiens
3.4.22.56NSC321206
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-3
Homo sapiens
3.4.22.56NSC310547
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-8
Homo sapiens
3.4.22.61NSC321205
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-8
Homo sapiens
3.4.22.61NSC277584
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-8
Homo sapiens
3.4.22.61NSC321206
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-8
Homo sapiens
3.4.22.61NSC310547
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)IGlycogen phosphorylase
Neurospora crassa
2.4.1.1Glucose-6-phosphate
(Glucose-1-phosphate)
[synthesis direction)]
Gold
(1974)
HMx(Sp=Ca)IGlycogen phosphorylase
Neurospora crassa
2.4.1.1Glucose-6-phosphate
(Glycogen)
[synthesis direction]
Gold
(1974)
HMx(Sp=Ca)IGlycogen phosphorylase
Neurospora crassa
2.4.1.1Glucose-6-phosphate
(Phosphate)
[phosphorolysis direction]
Gold
(1974)
HMx(Sp=Ca)IGlycogen phosphorylase
Neurospora crassa
2.4.1.1Glucose-6-phosphate
(Glycogen)
[phosphorolysis direction]
Gold
(1974)
HMx(Sp=Ca)IPeroxiredoxin
Homo sapiens
1.11.1.154-Methylcatechol
(H2O2)
Chow
(2016)
HMx(Sp=Ca)ISucrose α-glucosidase
Mus musculus
(Balb c)
3.2.1.48 Na+
(Sucrose)
[pH = 8.5]
Gupta
(2009)
HMx(Sp=Ca)ICaspase-7
Homo sapiens
3.4.22.60 NSC321206
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HMx(Sp=Ca)ICaspase-2
Homo sapiens
3.4.22.55 NSC321205
(Cbz-Asp-Glu-Val-Asp)2 Rhodamine 110)
Feldman
(2012)
HCaAGlutamate dehydrogenase (NAD(P)+)
Not specified
1.4.1.3 ADP
(NADPred)
Frieden
(1963)
HCaA Thioglucosidase
Raphanus sativus
3.2.1.147Ascorbate
(Sinigrin)
Shikita
(1999)
HCaAAmidase
Pseudomonas aeruginosa
3.5.1.4 Hydroxylamine
(Acetamide)
Woods
(1979)
HCaAPeroxidase
Armoracia rusticana
1.11.1.7 Melamine
(o-Phenylenediamine)
[pH = 7.4]
Karaseva
(2003)
HMx(Sp>Ca)APhospholipase A2 (Ammodytoxin A)
Vipera ammodytes ammodytes
3.1.1.4Calmodulin
(1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-
3-phosphoglycerol)
[non-reducing conditions]
Kovačič
HMx(Sp>Ca)APhospholipase A2 (Ammodytoxin A)
Vipera ammodytes ammodytes
3.1.1.4Calmodulin
(1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-
3-phosphoglycerol)
[reducing, cytosol-like conditions]
Kovačič
HMx(Sp>Ca)APhospholipase A2 (Ammodytoxin C)
Vipera ammodytes ammodytes
3.1.1.4Calmodulin
(1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-
3-phosphoglycerol)
[non-reducing conditions]
Kovačič
HMx(Sp>Ca)APhospholipase A2 (Ammodytoxin C)
Vipera ammodytes ammodytes
3.1.1.4Calmodulin
(1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-
3-phosphoglycerol)
[reducing, cytosol-like conditions]
Kovačič
HMx(Sp<Ca)ACholinesterase
Homo sapiens
3.1.1.8Tyramine
(o-Nitrophenylacetate)
Masson
(2008)
HMx(Sp<Ca)ACholinesterase
Homo sapiens
3.1.1.8Tyramine
(o-Nitroacetanilide)
Masson
(2008)
HMx(Sp>Ca)A3-Phosphoshikimate 1-carboxyvinyltransferase
Bacillus subtilis
2.5.1.19Shikimate-3-phosphate
(Phosphoenol pyruvate)
[100 mM NH4Cl]
Fischer
(1987)
HMx(Sp>Ca)A3-Phosphoshikimate 1-carboxyvinyltransferase
Bacillus subtilis
2.5.1.19Phosphoenol pyruvate
(Shikimate-3-phosphate)
[100 mM NH4Cl]
Fischer
(1987)
HSpASucrose α-glucosidase
Mus musculus (Balb c)
3.2.1.48Na+
(Sucrose)
[pH = 7.2]
Gupta
(2009)
HSpASucrose α-glucosidase
Rattus norvegicus
3.2.1.48Na+
(Sucrose)
[pH = 5.4]
Semenza
(1969)
HSpASucrose α-glucosidase
Hamster (species not mentioned)
3.2.1.48Na+
(Sucrose)
[pH = 5.4]
Semenza
(1969)
HSpA5'-Nucleotidase
Legionella pneumophila
3.1.3.5GTP
(GMP)
Srinivasan
(2014)
HMx(Sp<Ca)AThrombin
Homo sapiens
3.4.21.5Na+
(H-(D)-Phe-pipecolyl-Arg-p-nitroanilide)
Wells (1992)
Di Cera (1995)
HMx(Sp<Ca)AThrombin
Homo sapiens
3.4.21.5hir55-65, C-terminal fragment of hirudin
(H-(D)-Phe-pipecolyl-Arg-p-nitroanilide)
Ayala (1994)
Di Cera (1995)
HMx(Sp<Ca)ACathepsin K
Homo sapiens
3.4.22.38Dermatan sulfate
(Cbz-Phe-Arg-7-amino-4-methylcoumarylamide)
Novinec
(2010)
HMx(Sp<Ca)A3-Phosphoshikimate 1-carboxyvinyltransferase
Bacillus subtilis
2.5.1.19NH4+
(Phosphoenol pyruvate)
Fischer
(1987)
HMx(Sp<Ca)A3-Phosphoshikimate 1-carboxyvinyltransferase
Bacillus subtilis
2.5.1.19NH4+
(Shikimate-3-phosphate )
Fischer
(1987)
HMx(Sp<Ca)AAldehyde dehydrogenase (NAD+)
Homo sapiens
1.2.1.3Alda-1
(NADox)
Belmont-Díaz
(2016)
HMx(Sp<Ca)ACholesterol 24-hydroxylase ( truncated: Δ(2-50))
Homo sapiens
1.14.14.25L-Glutamate
(Cholesterol)
Mast
(2017)
HMx(Sp<Ca)ACholesterol 24-hydroxylase ( truncated: Δ(2-50))
Homo sapiens
1.14.14.25L-Glutamate
( NADPH-hemoprotein reductase, EC 1.6.2.4)
Mast
(2017)
HMx(Sp<Ca)APyruvate carboxylase
Sus scrofa
6.4.1.1Acetyl-CoA
(MgATP2-)
Warren
(1974)
HMx(Sp=Ca)ASucrose α-glucosidase
Mus musculus (Balb c)
3.2.1.48Na+
(Sucrose)
[pH = 5.0]
Gupta
(2009)
HMx(Sp=Ca)ATrypsin
Bos taurus
3.4.21.4Methylammonium
(Acetyl-Gly ethyl ester)
[0.1 M KCl]
Inagami
(1964)
HMx(Sp=Ca)ATrypsin
Bos taurus
3.4.21.4Ethylammonium
(Acetyl-Gly ethyl ester)
[0.1 M KCl]
Inagami
(1964)
HMx(Sp=Ca)ATrypsin
Bos taurus
3.4.21.41-Propylammonium
(Acetyl-Gly ethyl ester)
[0.1 M KCl]
Inagami
(1964)
HMx(Sp=Ca)ATrypsin
Bos taurus
3.4.21.4Methylguanidine
(Acetyl-Gly ethyl ester)
Inagami
(1968)
HMx(Sp=Ca)ATrypsin
Bos taurus
3.4.21.4Ethylguanidine
(Acetyl-Gly ethyl ester)
Inagami
(1968)
HMx(Sp=Ca)AMyeloblastin
Homo sapiens
3.4.21.76Chondroitin sulfate
(MeO-Suc-AAPV-7-amino-4-methylcoumarylamide)
Früh
(1996)
HMx(Sp=Ca)AMyeloblastin
Homo sapiens
3.4.21.76Dermatan sulfate
(MeO-Suc-AAPV-7-amino-4-methylcoumarylamide)
Früh
(1996)
HMx(Sp=Ca)AMyeloblastin
Homo sapiens
3.4.21.76Glycosaminoglycan polysulfate
(MeO-Suc-AAPV-7-amino-4-methylcoumarylamide)
Früh
(1996)
HMx(Sp=Ca)ALong-chain fatty acid omega-monooxygenase
Homo sapiens
1.14.13.205Dithiothreitol
(Lauric acid)
[enzyme: wild type]
Albertolle
(2017)
HMx(Sp=Ca)ALong-chain fatty acid omega-monooxygenase
Homo sapiens
1.14.13.205Dithiothreitol
(Lauric acid)
[enzyme: F434S variant]
Albertolle
(2017)
HMx(Sp<Ca)ITyrosinase
Agaricus bisporus
1.14.18.1Chloride anion, Cl
(L-Dopa)
Park
(2005)
LMx(Sp>Ca)IABC-type quaternary amine transporter
Homo sapiens
7.6.2.9Compound 9
(γ-Aminobutyric acid)
Al-Khawaja
(2014)
LSpIABC-type quaternary amine transporter
Mus musculus
7.6.2.9Compound 9
(γ-Aminobutyric acid)
Al-Khawaja
(2014)
HMx(Sp<Ca)ATryptophan synthase
Salmonella typhimurium
4.2.1.20Na+
(Indole)
Peracchi
(1995)
HSpIAldehyde dehydrogenase (NAD+)
Ovis aries
1.2.1.3Propionaldehyde
(4-Nitrophenylacetate)
[Esterase activity]
Blackwell
(1983)
HSpA1-Phosphatidylinositol
phosphodiesterase
Bacillus subtilis
3.1.4.10Butyl-fluorescein myo-inositol phosphate
(Butyl-fluorescein myo-inositol phosphate)
[activation by substrate]
Birrell
(2003)
HMx(Sp<Ca)A1-Phosphatidylinositol
phosphodiesterase
Bacillus subtilis
3.1.4.10Dihexanoylphosphatidylcholine
and
Butyl-fluorescein myo-inositol phosphate
(Butyl-fluorescein myo-inositol phosphate)
[nonessential activation + activation by substrate]
Birrell
(2003)
HSpIFerredoxin-nitrite reductase
Chlamydomonas reinhardtii
1.7.7.1Nitrate
(Nitrite)
Córdoba
(1986)
HMxD(I/A)Dipeptidyl-peptidase I (tetramer)
Homo sapiens
3.4.14.13'-Nitrophthalanilic acid
(H-Gly-Phe-7-amino-4-methylcoumarylamide)
Rebernik
(2019)
HMx(Sp<Ca)Abeta-Glucosidase
Bacillus polymyxa
3.2.1.21Glucose-6-phosphate
(p-nitrophenyl β-D-glucopyranoside)
Weiss
(2015)
HMx(Sp<Ca)IDipeptidyl-peptidase I (monomer)
Homo sapiens
3.4.14.13'-Nitrophthalanilic acid
(H-Gly-Phe-7-amino-4-methylcoumarylamide)
Rebernik
(2019)
HMx(Sp>Ca)AStreptopain
Streptococcus pyogenes
3.4.22.10Human Cystatin C
(Human IgG)
Vincents
(2008)
LMx(Sp>Ca)IProton-translocating NAD(P)+ transhydrogenase
Escherichia coli
7.1.1.15'-AMP
(NADPred)
Hanson
(1979)
LMx(Sp<Ca)IProton-translocating NAD(P)+ transhydrogenase
Escherichia coli
7.1.1.12'AMP
(3-Acetylpyridine adenine dinucleotide)
Hanson
(1979)
HMx(Sp=Ca)AHtrA2 peptidase
Homo sapiens
3.4.21.108HAX-1: Hematopoietic cell-specific protein 1 (HS1)-associated protein X-1
(Fluorescein isothiocyanate-labeled β-casein)
[Binding of modifier is cooperative]
Chaganti
(2019)
LCaITyrosinase
Agaricus bisporus
1.14.18.1[1,4’] Bipiperidinyl-1’-yl-naphthan-2-yl-methanone
(4-[(4-methylbenzo)azo]-1,2-benzendiol))
Karbassi
(2004)
HSpIReceptor protein-tyrosine kinase
Homo sapiens
2.7.10.1RG 14467
(ATP)
Hsu
(1991)
HSpILeukocyte elastase
Homo sapiens
3.4.21.37Heparin
(Suc-Ala3-p-nitroanilide)
Spencer
(2006)
HSpIPurine nucleosidase
Trypanosoma vivax
3.2.2.2Dromedary antibody variable domain fragment (VHH 1602)
(p-nitrophenyl riboside)
Barlow
(2009)
HMx(Sp<Ca)IPurine nucleosidase
Trypanosoma vivax
3.2.2.2Dromedary antibody variable domain fragment (VHH 1589)
(p-nitrophenyl riboside)
Barlow
(2009)
HSpIPyruvate kinase
Homo sapiens
2.7.1.40L-Phenylalanine
(Phosphoenolpyruvate)
Macpherson
(2019)
HMx(Sp=Ca)ANon-specific serine/threonine protein kinase
Species undeclared
2.7.11.1Pyrvinium
(α-Casein)
Shen
(2019)
HMx(Sp<Ca)ALeukotriene-A4 hydrolase
Homo sapiens
3.3.2.64MDM
(L-Ala-p-nitroanilide)
Lee
(2019)
HMx(Sp>Ca)ALeukotriene-A4 hydrolase
Homo sapiens
3.3.2.6ARM1
(L-Ala-p-nitroanilide)
Lee
(2019)
HMx(Sp>Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37EDTA
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Tyagi
(1991)
HMx(Sp=Ca)ILeukocyte elastase
Homo sapiens
3.4.21.37FURA2
(MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide)
Tyagi
(1991)
HMx(Sp=Ca)IReceptor protein-tyrosine kinase
Homo sapiens
2.7.10.1RG 14467
(Peptide K1)
Hsu
(1991)
HMx(Sp>Ca)IReceptor protein-tyrosine kinase
Homo sapiens
2.7.10.1Lavendustin A
(ATP)
Hsu
(1991)
LSpIbeta-Galactosidase
Escherichia coli
3.2.1.23β-D-1-thiogalactopyranoside (IPTG)
(Resorufin β-D-galactopyranoside)
Hess
(2015)
LSpI3-Hydroxyacyl-[acyl-carrier-protein] dehydratase
Yersinia pestis
4.2.1.59Mangostin
(Crotonyl-coenzyme-A)
McGillick
(2016)
LSpICaspase-3
Homo sapiens
3.4.22.56Designed ankyrin repeat protein D3.4
(N-Acetyl-DEVD-7-amino-4-methylcoumarylamide)
Schroeder
(2013)
HMxD(I/A)beta-Glucosidase
Humicola insolens
Mutant: D237V/P389H/E395G/K475R
3.2.1.21Glucose
(p-nitrophenyl-β-D-glucopyranoside)
Meleiro
(2017)
HMxD(I/A)beta-Glucosidase
Humicola insolens
Mutant: N89Y/H307Y
3.2.1.21Xylose
(p-nitrophenyl-β-D-glucopyranoside)
Meleiro
(2017)
LMx(Sp>Ca)IPyridoxal 5'-phosphate synthase
Escherichia coli
1.4.3.5Pyridoxal 5'-phosphate
(Pyridoxine 5'-phosphate)
[allosteric feedback product inhibition]
Barile
(2019)
LMx(Sp>Ca)Ibeta-Galactosidase
Escherichia coli
3.2.1.23Glycofullerene 10 (see orig. paper, Supplement, p. 19)
(p-Nitrophenyl β-D-Galactopyranoside)
Abellán Flos
(2016)
LCaIbeta-Galactosidase
Escherichia coli
3.2.1.23Glycofullerene 14 (see orig. paper, Supplement, p. 27)
(p-Nitrophenyl β-D-Galactopyranoside)
Abellán Flos
(2016)
HMx(Sp>Ca)ACoagulation factor VIIa
Homo sapiens
3.4.21.21Phosphatidylcholine + phosphatidylserine vesicles
(Coagulation factor X)
Krishnaswamy
(1992)